• Supplemental antioxidants may reduce exacerbations in cystic fibrosis
    on July 2, 2018 at 3:10 pm

    An antioxidant-enriched vitamin may decrease respiratory exacerbations in people with cystic fibrosis (CF), according to new research. […]

  • Cystic fibrosis bacterial burden begins during first years of life
    on January 19, 2018 at 7:12 pm

    Cystic fibrosis shortens life by making the lungs prone to repeated bacterial infections and inflammation. Researchers have now shown for the first time that the lungs' bacterial population changes in the first few years of life as respiratory infections and inflammation set in. This research offers a way to predict the onset of lung disease in children with CF and suggests a larger role for preventive therapies, such as hypertonic saline. […]

  • Treatment strategies for multidrug-resistant chronic infections
    on January 5, 2018 at 5:39 pm

    A new study finds that antibiotic treatment of chronic infections can be optimized by targeting vulnerabilities of antibiotic-resistant pathogens paving the way for more effective treatment strategies. […]

  • Defect in zinc supply mechanism affects pathology of intractable pulmonary diseases
    on December 28, 2017 at 3:09 pm

    Researchers revealed that abnormal delivery of zinc to lung cells contributes to obstructive pulmonary diseases. They further showed that mRNA splicing abnormalities are involved in the detailed mechanism. So far, the importance of zinc in the lung has only been understood from a nutritional aspect. This discovery is thought to be the first to clarify zinc's effects on the regulation of mRNA ligation (splicing), and its involvement in the onset of pulmonary diseases. […]

  • Protein structure could unlock new treatments for cystic fibrosis
    on December 13, 2017 at 7:36 pm

    Biochemists have used cryo-electron microscopy to determine the detailed architecture of the chloride channel TMEM16A. This protein is a promising target for the development of effective drugs to treat cystic fibrosis. […]

  • Cystic fibrosis: Discovery of a key molecule for improving treatments
    on December 12, 2017 at 3:22 pm

    Researchers identify a promising avenue for improving treatments for people with cystic fibrosis. They found that adding molecules called quorum-sensing inhibitors to current drugs not only reduces bacterial production of certain harmful residues but also restores the efficacy of existing treatments, such as Orkambi and Kalydeco, on the cells of cystic fibrosis patients. This breakthrough paves the way for new personalized therapies. […]

  • Health of people with cystic fibrosis shows positive trends in US and Canada
    on November 21, 2017 at 8:58 pm

    Research comparing cystic fibrosis patients in the United States and Canada showed that, although patients' nutritional status and lung function improved in both countries from 1990 to 2013, the US improvement rate was faster. Nutritional status and lung function are related to survival in cystic fibrosis. U.S. improvements may be due to implementation of newborn screening, quality improvement initiatives for the disease and better healthcare access under the Medicaid Children's Health Insurance Program, signed into federal law in 1997. […]

  • New simple test could help cystic fibrosis patients find best treatment
    on November 21, 2017 at 5:14 pm

    While new CF drugs are life-changing for some patients, they don't work for everyone. Now, researchers present a simple test that aims to predict which treatment is most likely to work for each patient, an approach known as personalized or precision medicine. […]